Laboratory for Pathology I
Department of Experimental Animal Facilities and Biorisk Management
Works in the entire field of pathology of infectious animal diseases (emphasis pathology of viral infections):
The laboratories for pathology and bacteriology are involved in the elucidation of pathogenetic mechanisms by investigation of morphological and functional changes during the course of infection. For this purpose, pathogenicity and virulence of infectious agents are characterized by histological, histochemical, immunohistological, and molecular pathological techniques.
The emphasis is laid on investigations of the cell and tissue tropism of viral pathogens, the interaction between virus and host including molecular pathogenesis. For this purpose, various diagnostic test methods have been established for the detection of antigens or nucleic acids in tissue sections by immunofluorescence or in situ hybridization and are continuously improved.
Bacteriological investigations are conducted to confirm the freedom of cell cultures and other biological test materials e.g. from mycoplasmas. Furthermore, bacteriological diagnostics are used to support pathomorphological findings.
Main research topics and projects:
- Pathogenetic investigations on the role of viral proteins for the neurovirulence of pseudorabies virus (PrV) in the mouse model and in vitro
- Comparative immunohistological investigations on the pathogenesis of classical and African swine fever in domestic pigs and wild boar
- Histopathological and molecular investigations on the pathogenesis of equine sarcoids and other papillomavirus infections of domestic animals
- Comparative pathogenetic studies on the viral neurotropism using PrV, lyssaviruses and teschoviruses as examples
- Immunohistological investigations on the tropism of avian and porcine influenza viruses
- Detection of mycoplasmas in cell cultures
- Pathogenesis of viral and bacterial mixed infections