Labor für Molekulare Pathogenese und Ökologie der Influenza-Viren
Institut für Molekularbiologie
Projekte
- Identifizierung von molekularen Virulenzdeterminanten aviärer Influenzaviren
- Einfluss von Veränderungen der viralen Polymerase auf die Virulenz
- Experimentelle Lebendvirusvakzinen durch Herstellung proteolytischer Aktivierungsmutanten
- Erforderliche Anpassungen aviärer Influenzaviren für den Speziesübergang auf den Säugerwirt
Publikationen
Ausgewählte Originalarbeiten
Stech O, Veits J, Weber S, Deckers D, Schröer D, Vahlenkamp TW, Breithaupt A, Teifke J, Mettenleiter TC, Stech J. (2009). Acquisition of a polybasic hemagglutinin cleavage site by a low-pathogenic avian influenza virus is not sufficient for immediate transformation into a highly pathogenic strain. J Virol. Jun;83(11):5864-8. Epub 2009 Mar 18.
Stech J, Stech O, Herwig A, Altmeppen H, Hundt J, Gohrbandt S, Kreibich A, Weber S, Klenk HD, Mettenleiter TC. (2008). Rapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplification.
Nucleic Acids Res. Dec;36(21):e139. Epub 2008 Oct 2.
Gabriel G, Garn H, Wegmann M, Renz H, Herwig A, Klenk HD, Stech J. (2008). The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine. Vaccine. Feb 13;26(7):956-65. Epub 2007 Dec 10.
Gabriel G, Abram M, Keiner B, Wagner R, Klenk HD, Stech J. (2007). Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J Virol. Sep;81(17):9601-4.
Gabriel G, Dauber B, Wolff T, Planz O, Klenk HD, Stech J. (2005). The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. PNAS. Dec 20;102(51):18590-5. Epub 2005 Dec 8.
Stech J, Garn H, Wegmann M, Wagner R, Klenk HD. (2005). A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin. Nat Med. Jun;11(6):683-9. Epub 2005 May 29.
Scholtissek C, Stech J, Krauss S, Webster RG. (2002). Cooperation between the hemagglutinin of avian viruses and the matrix protein of human influenza A viruses. J Virol. 2002 Feb;76(4):1781-6.
Hoffmann E, Stech J, Guan Y, Webster RG, Perez DR. (2001). Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol. Dec;146(12):2275-89.
Hoffmann E, Stech J, Leneva I, Krauss S, Scholtissek C, Chin PS, Peiris M, Shortridge KF, Webster RG. (2000). Characterization of the influenza A virus gene pool in avian species in southern China: was H6N1 a derivative or a precursor of H5N1? J Virol. Jul;74(14):6309-15.
Stech J, Xiong X, Scholtissek C, Webster RG. (1999). Independence of evolutionary and mutational rates after transmission of avian influenza viruses to swine. J Virol. 1999 Mar;73(3):1878-84.
Riberdy JM, Flynn KJ, Stech J, Webster RG, Altman JD, Doherty PC. (1999). Protection against a lethal avian influenza A virus in a mammalian system. J Virol. Feb;73(2):1453-9.
Übersichtsarbeiten
Stech J. (2010). Several hemagglutinins of same serotype for induction of broad immunity against influenza A virus antigenic drift variants: WO2008048984. Expert Opin Ther Pat. Mar;20(3):447-50.
Matrosovich M, Stech J, Klenk HD. (2009). Influenza receptors, polymerase and host range. Rev Sci Tech. Apr;28(1):203-17. Review.
Stech J. (2008). Attenuated influenza A viruses with modified cleavage sites in hemagglutinin as live vaccines. Expert Rev Vaccines. Aug;7(6):739-43. Review.
Stech, J. (2008). Influenza A Virus Polymerase: A Determinant of Host Range and Pathogenicity. p. 187-194. In Klenk, H.-D., Matrosovich, M. N., Stech, J. (eds.), Avian Influenza, Monographs in Virology, Vol. 27. Karger, Basel.
Klenk, H. D., Matrosovich, M.N., Stech, J. (2007). Avian Influenza: Molecular Mechanisms of Pathogenesis and Host Range. p. 253-303. In Mettenleiter, T. C., Sobrino, F. (eds.), Animal Viruses: Molecular Biology. Caister Academic Press.
Stech, J., Garn, H., Klenk, H.-D. (2006). A New Approach to an Influenza Live Vaccine: Modification of Cleavage Site of the Haemagglutinin by Reverse Genetics. p. 169-187. In Bogner, E., Holzenburg, A. (eds.), New Concepts in Molecular Virology. Springer, Dordrecht, The Netherlands.